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The Restylane family of products includes Restylane, Restylane-L, Perlane, and Perlane-L. These products can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane may also be used for lip enhancement in patients over 21 years. Ask your doctor which is right for you.
How does Perlane work?
Just like Restylane, Perlane adds volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).
Like Restylane, Perlane is a clear gel formulation of hyaluronic acid that is specifically formulated to add volume like your body’s own hyaluronic acid.
What makes Perlane different is the average size of the particles and the depth of injection. On average, the gel particles in Perlane are larger than those in Restylane, which makes Perlane a good choice for wrinkles that benefit from a deeper injection into the skin.
In three clinical studies of 150 patients each, on average 70% of patients maintained improvement for six months after just one Perlane treatment.
What is Hyaluronic Acid?
A large percentage of our skin (approximately 56%) is made up from Hyaluronic Acid (HA), a highly absorbent substance that hydrates and creates volume. As we age, our levels of HA decrease, causing fine lines, wrinkles and dehydrated skin. Luckily, help is at hand with Restylane – a HA gel that is injected directly into the skin to boost its appearance. There are a range of products available to suit every treatment need and subtly minimize creases and revive the complexion.
NASHA™ The science behind Restylane
NASHA (Non-Animal Stabilized Hyaluronic Acid) is the patented technology which is used in all of Restylane range of products. The hyaluronic acid is stabilized to create a long-acting substance. The stabilization involves the binding together of the HA molecules in a network.
Without this modification the hyaluronic acid would only stay in the tissue for days. Conversely, too much modification can affect the HA’s most important properties negatively.
NASHA is based on a non-animal (biosynthetic) raw material which gives it a high degree of purity. The gel is only stabilized by less than one per cent which ensures a long lasting effect as well as minimal tissue disturbance which reduces the risk of allergic reactions. NASHA’s properties also allow it to be integrated naturally into the body so that nutrients, hormones and other vital substances can pass through the gel.
Use of NASHA technology is clinically proven, with over 10 million treatments worldwide and an excellent safety profile of 1 in 20,000 patients experiencing an adverse event.
During your consultation, your healthcare professional will decide which product is right for you.
Important Safety Considerations for the Restylane family of products
Products in the Restylane family should not be used by people with previous bad allergies, particularly to microorganisms known as gram-positive bacteria, or by people with serious allergies to drugs that have previously required in-hospital treatment. These products should not be used by people with bleeding disorders. Products should not be injected anywhere except the skin, just under the skin (Perlane and Perlane-L only), or in the lips (Restylane only). Restylane-L and Perlane-L should not be used by anyone with a known allergy to lidocaine.
Use at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. In these instances, product use could delay healing or make your skin problems worse. After treatment, you might have some swelling, redness, pain, bruising, or tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years. Rarely, the doctor may inject into a blood vessel, which can damage the skin. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause an outbreak. To avoid bruising and bleeding, you should not use the products if you have recently used drugs that thin your blood or prevent clotting. Products should not be used during pregnancy, when breastfeeding, or in patients under 18 years for nasolabial folds.
Treatment volume should be limited to 6.0 mL in wrinkles and folds, such as nasolabial folds, and limited to 1.5 mL per lip (Restylane only), as greater amounts significantly increase moderate and severe injection site reactions. The safety or effectiveness of treatment in areas other than nasolabial folds and lips (Restylane only) has not been established in controlled clinical studies.